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KMID : 1161420180210111137
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Journal of Medicinal Food
2018 Volume.21 No. 11 p.1137 ~ p.1144
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Aqueous Extract of Taegeuk Ginseng Inhibits Platelet Aggregation and Thrombus Formation
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Do Jae-Ho
Gwak Jung-Won
Rho Jung-Jin
Lee Kwang-Seung
Irfan Muhammad
Rhee Man-Hee
Kim Dong-Chung
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Abstract
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The inhibitory effects of taegeuk ginseng extract (TGE) on platelet aggregation and thrombus formation were investigated. The TGE significantly inhibited collagen- and adenosine 5′-diphosphate (ADP)-induced platelet aggregation in vitro in a dose-dependent manner. Also oral administration of TGE to rats significantly prevented ADP- and collagen-induced platelet aggregation ex vivo, but it did not affect the plasma coagulation system. The oral administration of TGE significantly delayed the occlusion of the carotid artery in ferrous chloride-treated rats in vivo. These results suggest that in vivo antithrombotic effect of TGE may be due to its inhibitory activity on platelet aggregation rather than on plasma coagulation.
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KEYWORD
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antithrombotic effect, platelet aggregation, taegeuk ginseng extract, thrombus formation
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